Hold the nail brush under warm water, so the bristles become wet. Squirt hand soap or other anti-bacterial soap onto the nail brush.
Hold the nail brush in your hand and place the bristles under each fingernail. Move the brush from side to side, making sure to cover all of the nail. Make sure that the soap creates a lather while doing scrubbing the nails.
After using the nail brush on all of the nails on one hand, rinse the brush under warm water to clean it. Repeat the same steps on the other hand. Towel dry your hands.